Case Studies

Class IV laser therapy for trapeziometacarpal joint osteoarthritis: Study protocol for a randomized placebocontrolled trial

The aim of this study is to assess the effect of Class IV laser therapy (LT) on pain and pinch strength in patients with thumb carpometacarpal (TCMC) OA.

Author : Ivan Medina‐Porqueres, Raquel Cantero‐Tellez

Photobiomodulation therapy reduces viral load and cell death in ZIKV-infected glioblastoma cell line

Zika is a neurotropic virus much studied in the last years because of rapid spread, and also a strong association between ZIKV congenital transmission and congenital Zika syndrome. This case study investigates the effect of PBM on ZIKV infection.

Author : Luisa Zupin, Ilaria Caracciolo, Paola Maura Tricarico, Giulia Ottaviani, Pierlanfranco D’Agaro, Sergio Crovella

Photobiomodulation therapy for male infertility

Male infertility is a clinical issue with a global burden that has been increasing in the recent years. In this report, we do a deep overview of the published studies, focusing on Photobiomodulation (PBM) therapy, with the aim of expanding the knowledge in the field of laser light for a rational utilization of irradiation in the clinical practice.

Author : Luisa Zupin, Lorella Pascolo, Stefania Luppi, Giulia Ottaviani, Sergio Crovella, Giuseppe Ricci

Human β-defensin 1 in follicular fluid and semen: impact on fertility

In this study, we investigate the possible involvement of β-defensins in female and male infertility in infertile couples.

Author : Luisa Zupin, Vania Polesello, Monica Martinelli, Stefania Luppi, Elena Giolo, Gabriella Zito, Federico Romano, Ludovica Segat, Sergio Crovella, Giuseppe Ricci

Antiviral properties of blue laser in an in vitro model of HSV-1 infection

In this study, we explore the antiviral properties of blue laser in an in vitro model of HSV-1 infection.

Preliminary study in a new protocol for the treatment of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and chemotherapy (CT)

The aim of this study is to evaluate the efficacy of laser therapy in patients affected by oral mucositis induced by chemotherapy and HSCT.

Author : Marina Consuelo Vitale, Carola Modaffari, Nunzia Decembrino, Feng Xiao Zhou, Marco Zecca, Patrizia Defabianis

Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells

In this study, we aim to understand whether PBM could have a beneficial impact on a post-surgery cellular model of HS.

Author : Paola M. Tricarico, Luisa Zupin, Giulia Ottaviani, Sabrina Pacor, Francette Jean-Louis, Michele Boniotto, Sergio Crovella

Laser surgical treatment of chronic graft-versus-host disease (cGvHD)-induced buccal mucosal sclerosis

In this study, we look at a patient suffering from stage-2 oral sclerotic cGvHD treated with a bilateral surgical release of fibrous bands performed using a blue light-emitting diode laser.

Ex vivo histological analysis of the thermal effects created by a 445-nm diode laser in oral soft tissue biopsy

The aim of this study is to evaluate, ex vivo, the histological effects of 445-nm diode laser (Eltech K-Laser srl, Treviso, Italy), during an oral soft tissue biopsy.

Author : Gaspare Palaia, Alessandra Impellizzeri, Gianluca Tenore, Federico Caporali, Paolo Visca, Alessandro Del Vecchio, Gabriella Galluccio, Antonella Polimeni, Umberto Romeo

Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

In this study, we explore the anti-cancer effect of 3 laser protocols, set at the most commonly used wavelengths, in B16F10 melanoma and oral carcinogenesis mouse models.

Author : Giulia Ottaviani, Valentina Martinelli, Katia Rupel, Nicoletta Caronni, Asma Naseem, Lorenzo Zandonà, Giuseppe Perinetti, Margherita Gobbo, Roberto Di Lenarda, Rossana Bussani, Federica Benvenuti, Mauro Giacca, Matteo Biasotto, Serena Zacchigna